Dette studie fra USA blev stoppet før tid, da man allerede havde påvist effekten ved korsettering af skoliose, og dermed ikke kunne forsvare at have kontrolgruppen uden korset:
Weinstein SL, Dolan LA, Wright JG, Dobbs MB. Effects of Bracing in Adolescents with Idiopathic Scoliosis N Engl J Med. 2013 Oct 17;369(16):1512-21.
Udklip fra Resultaterne af studiet omkring bæretid på 12,9 timer/dag eller over for bedst effekt af korsettering:
BRACE DOSE–RESPONSE RELATIONSHIP
The majority of patients assigned to bracing (68%) were treated with a customized Boston-type thora- columbosacral orthosis. Temperature data were available for 116 patients (from both the random- ized and preference cohorts). During the first 6 months, patients wore the brace for a mean (±SD) of 12.1±6.5 hours per day (range, 0 to 23.0). The quartile of duration of brace wear was positively associated with the rate of success (P<0.001). The lowest quartile of wear (mean hours per day, 0 to 6.0) was associated with a success rate (41%) sim- ilar to that in the observation group in the pri- mary analysis (48%), whereas brace wear for an average of at least 12.9 hours per day was associated with success rates of 90 to 93% (Fig. 2).
Bracing significantly decreased the progression of high-risk curves to the threshold for surgery in patients with adolescent idiopathic scoliosis. The benefit increased with longer hours of brace wear.
Vigtigheden af bæretid i korset er allerede belyst i dette studie fra 1997:
Rowe DE, Bernstein SM et al. A meta-analysis of the efficacy of non-operative treatments for idiopathic scoliosis. J Bone Joint Surg Am. 1997 May;79(5):664-74.
We found that use of the Milwaukee brace or another thoracolumbosacral orthosis for twenty-three hours per day effectively halted progression of the curve. Bracing for eight or sixteen hours per day was found to be significantly less effective than bracing for twenty-three hours per day
Studie omkring vigtigheden af korrektion i korsettet samt bæretid for slutresultatet:
Landauer F, Wimmer C, Behensky H. Estimating the final outcome of brace treatment for idiopathic thoracic scoliosis at 6-month follow-up. Pediatr Rehabil. 2003 Jul-Dec;6(3-4):201-7.
Compliant patients with a high initial correction can expect a final correction of around 7 degrees, while compliant patients with low initial correction may maintain the curve extent. Bad compliance is always associated with curve progression.
Nachemson AL, Peterson LE. Effectiveness of treatment with a brace in girls who have adolescent idiopathic scoliosis. A prospective, controlled study based on data from the Brace Study of the Scoliosis Research Society. J Bone Joint Surg Am. 1995 Jun;77(6):815-22.
According to survivorship analysis, treatment with a brace was associated with a success rate of 74 per cent (95 per cent confidence interval, 52 to 84) at four years; observation only, with a success rate of 34 per cent (95 per cent confidence interval, 16 to 49); and electrical stimulation, with a success rate of 33 per cent (95 per cent confidence interval, 12 to 60)